Birth-date specific plasticity of cortical neurons

12:00 - 12:30

Day 3 – February 7, 2025

Abstract

Here I will expose how FACS can help us untangle a fundamental question in neurodevelopment: the interaction between genetic and environmental factors in acquisition of neuronal identity. To address this question, I labelled developing neurons in utero in mouse embryos and used FACS to isolate cells based on their time of birth. These cells were then transplanted into a new host, but in a different environment. We assessed the identity of the transplanted neurons before and after transplantation by examining their molecular, transcriptomic, electrophysiological, and morphological profile. I will present these results and show how this approach allows us to disentangle the relative contributions of intrinsic genetic programs and extrinsic environmental cues in shaping neuronal identity during development.

The speakers