Speakers

Our long-term vision is to understand how the bone marrow (BM) niche integrates genetic programs, epigenetic states, and extrinsic cues to maintain hematopoietic homeostasis and respond to perturbations. In this talk, I will argue that gene regulation—particularly the interplay between transcription factors and enhancers—plays a pivotal role in determining cellular identity and function within the BM microenvironment. I will present insights from single-cell RNA and chromatin profiling that reveal key gene regulatory networks shaping niche composition and hematopoietic differentiation. I will showcase findings from two ongoing studies: one investigating the role of T cells in BM niche remodeling during allogeneic hematopoietic cell transplantation (allo-HCT), and another examining how the BM niche undergoes transformation in hematological malignancies. These studies illustrate how niche cell states and signaling dynamics are altered in response to external cues, providing a deeper understanding of the molecular mechanisms that influence disease progression, remission, and relapse.